Apolypoprotein E gene polymorphism, gallstone disease, diabetes 2 type and lipid metabolism disorders

Aim of the study was to explore impact apolipoprotein E ( APOE ) gene polymorphisms (GP) on gallstone disease (GSD) and type 2 diabetes mellitus (DM2) its role in lipid metabolism. APOE4 allele carriers had highest levels plasma bile cholesterol lowest acids than other alleles. In GSD a higher frequency (2.6 times compared control) found. risk reduced by 12 % APOE2 APOE3/3. Our 20-year research confirms association GP GSD. The ε4/ε4 genotype is people aged 18–35 years with family history (5.8 %) population Novosibirsk (1.8 %, p < 0.05). more lithogenic GSD: level 8.0 ± 0.5 versus 6.9 0.6 g/l ε3/ε3 genotype. cholate-cholesterol ratio 6.4 0.7 12.9 0.2 0.05) absence APOE4. women hypertension, presence associated combination low density (LDL-C) > 3.5 mmol/l carriage. DM2 recognized factor for most common opinion that ε4 an independent DM2, some authors consider APOE2. Moreover, patients ε3/ε4 have increase total cholesterol, LDL-C non-high-density lipoprotein ε3/ε3. Other studies not found any associations between or DM2. inconsistency data can be explained heterogeneity included groups methods genotyping, which requires further research.